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Th1 Cytokines Facilitate CD8-T-Cell-Mediated Early Resistance to Infection with<i>Mycobacterium tuberculosis</i>in Old Mice

19 May 2006

Abstract excerpt

Numerous immunological defects begin to emerge as an individual ages, the consequence of which is heightened susceptibility to infectious diseases. Despite this decline in immune function, old mice display an early transient resistance to Mycobacterium tuberculosis infection in the lung, which is dependent on CD8 T cells and gamma interferon (IFN-gamma) production. In this study, we investigated the mechanism of...

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PMID: 16714559
DOI: 10.1128/iai.01475-05

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