Article
Differential regulation of human fibroblast growth factor 1 transcripts provides a distinct mechanism of cell-specific growth factor expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1997
Chotani M A, Chiu I M
Abstract excerpt
Four variants of fibroblast growth factor 1 (FGF-1) mRNA, FGF-1.A, -1.B, -1.C, and -1.D, originate from four discrete promoters of the gene. Each promoter is coupled with its 5'-untranslated exon. These four promoters are separated by as much as 70 kbp in the FGF-1 locus. The present study indica...
Topics
- Cell Line
- Cells, Cultured
- Dactinomycin
- Fibroblast Growth Factors
- Gene Expression Regulation
- Genetic Variation
- Growth Substances
- Heparin
- Humans
- Promoter Regions, Genetic
- RNA, Messenger
- Transcription, Genetic
- Transforming Growth Factor beta
- Tumor Cells, Cultured