Article
Deletion of the copper transporter CaCCC2 reveals two distinct pathways for iron acquisition in Candida albicans.
Molecular microbiology - 1 Jun 2002
Weissman Ziva, Shemer Revital, Kornitzer Daniel
Abstract excerpt
Efficient iron acquisition is an essential requirement for growth of pathogenic organisms in the iron-poor host environment. In Saccharomyces cerevisiae, high-affinity iron import depends on the multicopper ferroxidase ScFet3. ScFet3 biogenesis in the trans-Golgi compartment requires a copper-transporting P-type ATPase, ScCcc2. Here, we describe the isolation by functional complementation of a Ccc2 homologue from...
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