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Article

An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.

Cell host & microbe - 18 Aug 2011

Chen Changbin, Pande Kalyan, French Sarah D, Tuch Brian B, Noble Suzanne M

Abstract excerpt

The mammalian gastrointestinal tract and bloodstream are highly disparate biological niches that differ in concentrations of nutrients such as iron. However, some commensal-pathogenic microorganisms, such as the yeast Candida albicans, thrive in both environments. We report the evolution of a transcription circuit in C. albicans that controls iron uptake and determines its fitness in both niches. Our analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21843869
DOI: 10.1016/j.chom.2011.07.005
PMCID: PMC3165008

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