Article
Expanded role of the Cu-sensing transcription factor Mac1p in Candida albicans.
Molecular microbiology - 1 Dec 2020
Culbertson Edward M, Bruno Vincent M, Cormack Brendan P, Culotta Valeria C
Abstract excerpt
As part of the innate immune response, the host withholds metal micronutrients such as Cu from invading pathogens, and microbes respond through metal starvation stress responses. With the opportunistic fungal pathogen Candida albicans, the Cu-sensing transcription factor Mac1p governs the cellular response to Cu starvation by controlling Cu import. Mac1p additionally controls reactive oxygen species (ROS)...
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