Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

doi:10.1200/JCO.2002.09.091

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Article

Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Jun 2002

Etienne Marie-Christine, Chazal Maurice, Laurent-Puig Pierre, Magné Nicolas, Rosty Christophe, Formento Jean-Louis, Francoual Mireille, Formento Patricia, Renée Nicole, Chamorey Emmanuel, Bourgeon André, Seitz Jean-François, Delpero Jean-Robert, Letoublon Christian, Pezet Denis, Milano Gérard

Abstract excerpt

PURPOSE: The aim of this multicenter prospective study was to evaluate the role of intratumoral parameters related to fluorouracil (FU) sensitivity in 103 metastatic colorectal cancer patients receiving FU-folinic acid. PATIENTS AND METHODS: Liver metastatic biopsy specimens were obtained for all patients and primary tumor biopsy specimens for 54 patients. Thymidylate synthase (TS), folylpolyglutamate synthetase,...

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PMID: 12065560
DOI: 10.1200/JCO.2002.09.091

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