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Article

Immortalization of human neural stem cells with the c-myc mutant T58A.

PloS one - 2 Oct 2008

De Filippis Lidia, Ferrari Daniela, Rota Nodari Laura, Amati Bruno, Snyder Evan, Vescovi Angelo Luigi

Abstract excerpt

Human neural stem cells (hNSC) represent an essential source of renewable brain cells for both experimental studies and cell replacement therapies. Their relatively slow rate of proliferation and physiological senescence in culture make their use cumbersome under some experimental and pre-clinical settings. The immortalization of hNSC with the v-myc gene (v-IhNSC) has been shown to generate stem cells endowed...

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Identifiers

PMID: 18836552
DOI: 10.1371/journal.pone.0003310
PMCID: PMC2561001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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