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Article

Transduction of Long-Term and Mobilized Peripheral Blood-Derived NOD/SCID Repopulating Cells by Foamy Virus Vectors

1 Jan 2004

Abstract excerpt

Foamy virus (FV) vectors are a promising gene delivery system for use in hematopoietic stem cell gene therapy. Previous FV vector marking studies in the NOD/SCID xenotransplantation model used umbilical cord blood (UCB)-derived SCID repopulating cells (SRCs) that were assayed 5-10 weeks posttransplantation. We now report efficient FV vector transduction (>65%) of UCB-derived primitive, long-term SRCs engrafted...

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Identifiers

PMID: 14965380
DOI: 10.1089/10430340460732481

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