Article
An electrochemical detection scheme for identification of single nucleotide polymorphisms using hairpin-forming probes.
Nucleic acids research - 15 Jun 2002
Huang Tony Jun, Liu Minghsun, Knight Linda D, Grody Wayne W, Miller Jeff F, Ho Chih-Ming
Abstract excerpt
Single nucleotide polymorphisms are implicated as having a significant role in regulating growth, development and, thereby, human health and disease. We have developed a method for identifying single nucleotide genetic alterations by combining hairpin-forming DNA probes and electrochemical detection of sandwich DNA hybridization. Incorporation of hairpin-forming competitor probes and the catalyzed reporter...
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