Article
Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X.
The American journal of pathology - 1 Jun 2002
Jacenko Olena, Roberts Douglas W, Campbell Michelle R, McManus Patricia M, Gress Catherine J, Tao Zhuliang
Abstract excerpt
Each skeletal element where marrow develops is first defined by a hypertrophic cartilage blueprint. Through programmed tissue substitution, the cartilaginous skeletal model is replaced by trabecular bone and marrow, with accompanying longitudinal tissue growth. During this process of endochondral ossification, hypertrophic cartilage expresses a unique matrix molecule, collagen X. Previously we reported that...
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