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Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene

1 Apr 1998

Abstract excerpt

The human cytoplasmic serine hydroxymethyltransferase (CSHMT) gene was isolated, sequenced and its expression characterized in human MCF-7 mammary carcinoma and SH_5Y5Y neuroblastoma cells. The 23-kb gene contains 12 introns and 13 exons; all splice junctions conform to the gt/ag rule. The open reading frame is interrupted by 10 introns, two of which are positionally conserved within the human mitochondrial SHMT...

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PMID: 9573390
DOI: 10.1016/s0378-1119(98)00085-7

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