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Article

Proteolytic Cleavage of the Linker Region of the Human P-glycoprotein Modulates Its ATPase Function.

The Journal of biological chemistry - 16 Aug 2002

Nuti Shanthy L, Rao U Subrahmanyeswara

Abstract excerpt

P-glycoprotein (Pgp), an anticancer drug-translocating ATPase, is responsible for multidrug resistance in cancer. We have previously shown (Nuti, S. L., Mehdi, A., and Rao, U. S. (2000) Biochemistry 39, 3424-3432) that tryptic cleavage of Pgp results in the activation of basal and drug-stimulated ATPase functions of Pgp. To understand this phenomenon, we determined the sites cleaved by trypsin and further...

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PMID: 12055198
DOI: 10.1074/jbc.M204054200

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