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Article

Leucine-induced dissociation of Escherichia coli Lrp hexadecamers to octamers.

Journal of molecular biology - 10 May 2002

Chen Shaolin, Calvo Joseph M

Abstract excerpt

Lrp is a global regulator of metabolism in Escherichia coli that helps cells respond to changes in environmental conditions. The action of Lrp as a transcriptional activator or repressor is sometimes affected when the medium contains exogenous leucine. In this study, we examined the thermodynamics of leucine binding to Lrp and to a leucine response mutant, Lrp-1, and leucine-induced dissociation of Lrp...

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PMID: 12054800
DOI: 10.1016/S0022-2836(02)00187-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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