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Article

The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.

Journal of molecular biology - 10 May 2002

Abad Marta C, Arni R K, Grella Davida K, Castellino Francis J, Tulinsky Alexander, Geiger James H

Abstract excerpt

Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle lysine-binding sites contain a bound bicine molecule...

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Source

Identifiers

PMID: 12054798
DOI: 10.1016/S0022-2836(02)00211-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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