Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystallization and preliminary X-ray diffraction studies of human angiostatin.

Acta crystallographica. Section D, Biological crystallography - 1 Mar 2002

Abad Marta C, Geiger James

Abstract excerpt

Angiostatin is an inhibitor of angiogenesis, the process by which new blood vessels are formed from pre-existing ones. The fact that tumor growth and metastasis dissemination are angiogenesis-dependent processes has awakened interest in angiogenesis inhibitors as anticancer treatment drugs. Angiostatin, a potent angiogenesis inhibitor, is currently in phase I clinical trials. Human angiostatin containing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallization
Share to Crystallography, X-Ray
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Peptide Fragments

Share to Plasminogen

Share to Protein Conformation

Source

Identifiers

PMID: 11856839
DOI: 10.1107/s0907444902000276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystallization and preliminary X-ray diffraction studies of human angiostatin.PMID 11856839Read ↗

The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.Semantic proximity Read ↗

Mutation of human plasminogen kringle 1-5 enhances anti-angiogenic action via increased interaction with integrin alpha(v)beta(3).Semantic proximity Read ↗

Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.Semantic proximity Read ↗

The X-ray crystal structure of full-length human plasminogen.Semantic proximity Read ↗

Angiostatin: a circulating endothelial cell inhibitor that suppresses angiogenesis and tumor growth.Semantic proximity Read ↗

Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogenSemantic proximity Read ↗

Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin.Semantic proximity Read ↗

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.Semantic proximity Read ↗

Disruption of interkringle disulfide bond of plasminogen kringle 1-3 changes the lysine binding capability of kringle 2, but not its antiangiogenic activity.Semantic proximity Read ↗

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptideSemantic proximity Read ↗

Angiostatin gene transfer: Inhibition of tumor growth <i>in vivo</i> by blockage of endothelial cell proliferation associated with a mitosis arrestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.