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Article

ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils.

Biochemical and biophysical research communications - 24 May 2002

Shiohara Masaaki, Taniguchi Shun'ichiro, Masumoto Junya, Yasui Kozo, Koike Kenichi, Komiyama Atsushi, Sagara Junji

Abstract excerpt

ASC is an adaptor protein that is composed of two protein-protein interaction domains, a PYRIN domain (PYD), and a caspase-recruitment domain (CARD). Recently, ASC was identified as a binding partner of pyrin, which is the product of MEFV, a gene causing familial Mediterranean fever (FMF). Mutati...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12054656
DOI: 10.1016/S0006-291X(02)00384-4

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12054656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils.PMID 12054656Read ↗

Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns.Semantic proximity Read ↗

Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.Semantic proximity Read ↗

Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues.Semantic proximity Read ↗

Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome AssemblySemantic proximity Read ↗

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.Semantic proximity Read ↗

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.Semantic proximity Read ↗

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.Semantic proximity Read ↗

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.Semantic proximity Read ↗

The PRY/SPRY Domain of Pyrin/TRIM20, The Familial Mediterranean Fever Protein, Interacts with β2-Microglobulin to Promote Inflammasome FormationSemantic proximity Read ↗

ASC filament formation serves as a signal amplification mechanism for inflammasomes.Semantic proximity Read ↗

Distinct interaction modes orchestrate the polymerization of ASC PYD and CARD domains into filamentous structures.Semantic proximity Read ↗

The PRY/SPRY domain of pyrin/TRIM20 interacts with β2-microglobulin to promote inflammasome formation.Semantic proximity Read ↗

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