Article
Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Nov 2012
Stephan Daniel, Sánchez-Soriano Natalia, Loschek Laura F, Gerhards Ramona, Gutmann Susanne, Storchova Zuzana, Prokop Andreas, Kadow Ilona C Grunwald
Abstract excerpt
The formation of neuronal circuits is a key process of development, laying foundations for behavior. The cellular mechanisms regulating circuit development are not fully understood. Here, we reveal Psidin as an intracellular regulator of Drosophila olfactory system formation. We show that Psidin is required in several classes of olfactory receptor neurons (ORNs) for survival and subsequently for axon guidance....
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