Article
Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene.
The Journal of clinical endocrinology and metabolism - 1 Jun 2002
Kinjo Yoshino, Takasu Nobuyuki, Komiya Ichiro, Tomoyose Takeaki, Takara Masaki, Kouki Tsuyoshi, Shimajiri Yoshinori, Yabiku Kouichi, Yoshimura Hiroshi
Abstract excerpt
We studied whether a patient with Graves' disease will go into remission during antithyroid drug (ATD) treatment. Remission of Graves' hyperthyroidism is predicted by a smooth decrease in TSH receptor antibody (TRAb) during ATD treatment. Cytotoxic T cell lymphocyte-associated molecule-4 (CTLA-4) may play an important role in the development of Graves' hyperthyroidism and in its remission. We studied A/G...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Antibodies
- Antithyroid Agents
- Exons
- Female
- Gene Frequency
- Genotype
- Graves Disease
- Humans
- Male
- Middle Aged