Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal.

doi:10.1210/jc.2003-030854

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Article

Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal.

The Journal of clinical endocrinology and metabolism - 1 Jan 2004

Wang Pei-Wen, Liu Rue-Tsuan, Juo Suh-Hang Hank, Wang Shan-Tair, Hu Ya-Hui, Hsieh Ching-Jung, Chen Ming-Hong, Chen I-Ya, Wu Chia-Ling

Abstract excerpt

We studied the A/G single nucleotide polymorphism (SNP) at position 49 in exon 1 of the cytotoxic T lymphocyte-associated molecule-4 gene in 148 Chinese Graves' disease (GD) patients and 171 controls. Our primary aim was to test for the association of this SNP with the relapse of the hyperthyroidism after antithyroid withdrawal. Our secondary aim was to investigate the relationship between GD patients and...

Topics

Adult
Alleles
Antigens, CD
Antigens, Differentiation
Antithyroid Agents
CTLA-4 Antigen
Female
Gene Frequency
Genotype
Graves Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Methimazole

Middle Aged

Odds Ratio

Polymorphism, Single Nucleotide

Propylthiouracil

Source

Open in PubMed

Identifiers

PMID: 14715845
DOI: 10.1210/jc.2003-030854

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