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Article

Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A.

The Journal of biological chemistry - 9 Aug 2002

Miyamoto Yuji, Machida Kiyotaka, Mizunuma Masaki, Emoto Yuji, Sato Naomi, Miyahara Kohji, Hirata Dai, Usui Takeo, Takahashi Hidetoshi, Osada Hiroyuki, Miyakawa Tokichi

Abstract excerpt

To dissect the action mechanism of reveromycin A (RM-A), a G(1)-specific inhibitor, a Saccharomyces cerevisiae dominant mutant specifically resistant to RM-A, was isolated from a strain in which the genes implicated in nonspecific multidrug resistance had been deleted. The mutant gene (YRR2-1) responsible for the resistance was identified as an allele of the ILS1 gene encoding tRNA(Ile) synthetase (IleRS). The...

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PMID: 12050165
DOI: 10.1074/jbc.M203827200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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