Decreased accumulation or increased isoleucyl-tRNA synthetase activity confers resistance to the cyclic beta-amino acid BAY 10-8888 in Candida albicans and Candida tropicalis.

doi:10.1128/AAC.42.7.1581

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Article

Decreased accumulation or increased isoleucyl-tRNA synthetase activity confers resistance to the cyclic beta-amino acid BAY 10-8888 in Candida albicans and Candida tropicalis.

Antimicrobial agents and chemotherapy - 1 Jul 1998

Ziegelbauer K

Abstract excerpt

BAY 10-8888, a cyclic beta-amino acid, exerts its antifungal activity by inhibition of isoleucyl-tRNA synthetase activity after accumulation to a millimolar concentration inside the cell. We have selected and characterized BAY 10-8888-resistant Candida albicans mutants. Reduced BAY 10-8888 accumu...

Topics

Candida
Candida albicans
Cell Division
Cycloleucine
Drug Resistance, Microbial
Isoleucine-tRNA Ligase
Microbial Sensitivity Tests
Mutation

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