Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial.

Atherosclerosis - 1 Jul 2002

Jamshidi Y, Flavell D M, Hawe E, MacCallum P K, Meade T W, Humphries S E

Abstract excerpt

Genetic determinants of baseline levels and the fall in plasma triglyceride and fibrinogen levels in response to bezafibrate treatment were examined in 853 men taking part in the lower extremity arterial disease event reduction (LEADER) trial. Three polymorphisms in the peroxisome proliferator activated receptor alpha (PPARalpha) gene were investigated (L162V, G>A in intron 2 and G>C in intron 7), two in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein C-III
Share to Apolipoproteins C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arterial Occlusive Diseases

Share to Double-Blind Method

Share to Drug Administration Schedule

Share to Fibrinogen

Share to Hypolipidemic Agents

Share to Peripheral Vascular Diseases

Source

Identifiers

PMID: 12048138
DOI: 10.1016/s0021-9150(02)00002-3

Genes

APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial.PMID 12048138Read ↗

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid.Semantic proximity Read ↗

Response to micronized fenofibrate treatment is associated with the peroxisome???proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetesSemantic proximity Read ↗

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.Semantic proximity Read ↗

Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.Semantic proximity Read ↗

Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients.Semantic proximity Read ↗

An association study of 43 SNPs in 16 candidate genes with atorvastatin response.Semantic proximity Read ↗

The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions.Semantic proximity Read ↗

Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study.Semantic proximity Read ↗

The PPAR alpha gene is associated with triglyceride, low-density cholesterol and inflammation marker response to fenofibrate intervention: the GOLDN study.Semantic proximity Read ↗

Lipoprotein lipase gene mutations, plasma lipid levels, progression/regression of coronary atherosclerosis, response to therapy, and future clinical events. Lipoproteins and Coronary Atherosclerosis Study.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease.Semantic proximity Read ↗

Effects of diet, drugs, and genes on plasma fibrinogen levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.