Article
The PPAR alpha gene is associated with triglyceride, low-density cholesterol and inflammation marker response to fenofibrate intervention: the GOLDN study.
The pharmacogenomics journal - 1 Aug 2013
Frazier-Wood A C, Ordovas J M, Straka R J, Hixson J E, Borecki I B, Tiwari H K, Arnett D K
Abstract excerpt
As a peroxisome proliferator-activated receptor alpha (PPARα) agonist, fenofibrate favorably modulates dyslipidemia and inflammation markers, which are associated with cardiovascular risk. To determine whether variation in the PPARα receptor gene was associated with lipid and inflammatory marker response, we conducted a 3-week trial of fenofibrate in 861 men and women. Mixed linear models that controlled for age...
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