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Article

Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease.

Circulation - 26 Mar 2002

Flavell David M, Jamshidi Yalda, Hawe Emma, Pineda Torra Inés, Taskinen Marja-Riitta, Frick M Heikki, Nieminen Markku S, Kesäniemi Y Antero, Pasternack Amos, Staels Bart, Miller George, Humphries Steve E, Talmud Philippa J, Syvänne Mikko

Abstract excerpt

BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD). METHODS AND RESULTS: We investigated the association between the leucine 162 to valine (L162V) polymorphism and a G to C transversion in intron 7 of the PPARalpha gene and...

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Source

Identifiers

PMID: 11914252
DOI: 10.1161/01.cir.0000012145.80593.25

Genes

NPHS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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