Article
The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jun 2002
Cinek O, Drevínek P, Sumník Z, Bendlová B, Kolousková S, Snajderová M, Vavrinec J
Abstract excerpt
We investigated the association of the CTLA4 +49 A/G dimorphism with type 1 diabetes in Czech children. Genotyping of 305 diabetic children and 289 controls by a novel PCR-ARMS assay revealed no significant differences in the genotypic or allelic frequencies. This may be another piece of evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene.
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