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Article

The Rb tumor suppressor regulates epithelial cell migration and polarity.

Molecular carcinogenesis - 1 Nov 2018

Parisi Tiziana, Balsamo Michele, Gertler Frank, Lees Jacqueline A

Abstract excerpt

Altered cell polarity and migration are hallmarks of cancer and metastases. Here we show that inactivation of the retinoblastoma gene (Rb) tumor suppressor causes defects in tissue closure that reflect the inability of Rb null epithelial cells to efficiently migrate and polarize. These defects occur independently of pRB's anti-proliferative role and instead correlate with upregulation of RhoA signaling and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30084175
DOI: 10.1002/mc.22886
PMCID: PMC6168347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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