Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras alters epithelial-mesenchymal transition in response to TGF-β by reducing actin fibers and cell-matrix adhesion

15 Jan 2009

Abstract excerpt

TGF-beta and Ras regulate epithelial-mesenchymal transition (EMT), a process that contributes to tumor invasion and metastasis. The interaction of these pathways in EMT is still poorly understood. Here, we show that TGF-beta induces EMT but limits cell invasion whereas hyperactivated Ras (H-RasV12) does not cause EMT but enhances cell invasion, alleviating the inhibitory effect of TGF-beta. TGF-beta disrupts cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Sarcoma Diagnosis and Treatment
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19177011
DOI: 10.4161/cc.8.2.7590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras alters epithelial-mesenchymal transition in response to TGF-β by reducing actin fibers and cell-matrix adhesionPMID 19177011Read ↗

TGF-β signaling and epithelial–mesenchymal transition in cancer progressionSemantic proximity Read ↗

Cytoskeletal signaling in <scp>TGF</scp>β‐induced epithelial–mesenchymal transitionSemantic proximity Read ↗

TGF-β in developmental and fibrogenic EMTsSemantic proximity Read ↗

TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell TransitionSemantic proximity Read ↗

Epithelial–mesenchymal transition is regulated at post‐transcriptional levels by transforming growth factor‐β signaling during tumor progressionSemantic proximity Read ↗

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.Semantic proximity Read ↗

TGF-beta and epithelial-to-mesenchymal transitions.Semantic proximity Read ↗

A Critical Role of Tropomyosins in TGF-β Regulation of the Actin Cytoskeleton and Cell Motility in Epithelial CellsSemantic proximity Read ↗

Regulation of EMT by TGFβ in cancerSemantic proximity Read ↗

aV integrins and TGF‐β‐induced EMT: a circle of regulationSemantic proximity Read ↗

RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition.Semantic proximity Read ↗

Reversible Smad-Dependent Signaling between Tumor Suppression and OncogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.