Article
Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila.
Mechanisms of development - 1 Dec 2002
Chen Li, O'Keefe Sandra L, Hodgetts Ross B
Abstract excerpt
The induction of the Dopa decarboxylase gene (Ddc) in the epidermis of Drosophila at pupariation is a receptor-mediated response to the steroid molting hormone, ecdysone. Activity is also dependent on the Broad-Complex (BR-C), an early ecdysone response gene that functions during metamorphosis. BR-C encodes a family of zinc-finger protein isoforms, BR-C(Z1-Z4). Genetic experiments have shown that the Z2 isoform...
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