Article
The functional specificity of NeuroD is defined by a single amino acid residue (N11) in the basic domain.
FEBS letters - 5 Jun 2002
Wang Xukun, Korzh Vladimir, Gong Zhiyuan
Abstract excerpt
In zebrafish, the basic helix-loop-helix (bHLH) gene neuroD specifies distinct neurons in the spinal cord. A preliminary experiment indicated that a related bHLH gene, ndr1a, normally expressed only in the olfactory organ in late embryos, also functions as neuroD to induce ectopic formation of spinal cord neurons in early embryos after introduction of its mRNA into early embryos. To define the functional...
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