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Article

Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1 alpha.

Immunogenetics - 1 May 2002

Dominici Roberto, Cattaneo Monica, Malferrari Giulia, Archi Davide, Mariani Claudio, Grimaldi Luigi Maria Edoardo, Biunno Ida

Abstract excerpt

A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region and determined its activity. The TT genotype significantly increased the transcriptional activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12037600
DOI: 10.1007/s00251-002-0445-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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