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Article

Cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in inflammatory breast carcinoma.

Oncogene - 16 May 2002

Alpaugh Mary L, Tomlinson James S, Kasraeian Sina, Barsky Sanford H

Abstract excerpt

Inflammatory breast carcinoma (IBC) is characterized by florid tumor emboli within lymphovascular spaces termed lymphovascular invasion (LVI). Using a human-scid model of IBC (MARY-X), we have demonstrated using retrovirally-mediated dominant-negative E-cadherin mutant approaches (H-2K(d)-E-cad), that the tumor cell embolus (IBC spheroid) forms on the basis of an intact and overexpressed E-cadherin/alpha,...

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Topics

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Share to Antigens, Tumor-Associated, Carbohydrate
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lewis Blood Group Antigens

Share to Mammary Neoplasms, Experimental

Share to Mice, SCID

Share to Mucin-1

Share to Neoplastic Cells, Circulating

Share to Oligosaccharides

Source

Identifiers

PMID: 12032865
DOI: 10.1038/sj.onc.1205389

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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