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Article

Behavioral and synaptic circuit features in a zebrafish model of fragile X syndrome.

PloS one - 1 Jan 2013

Ng Ming-Chong, Yang Yi-Ling, Lu Kwok-Tung

Abstract excerpt

Fragile X syndrome (FXS) is the most frequent inherited form of human mental retardation. It is characterized by cognitive impairment and physical and behavioral problems and is caused by the silencing of fmr1 transcription and the absence of the fmr1 protein (FMRP). Recently, animal models of FXS have greatly facilitated the investigation of the molecular and cellular mechanisms of this loss-of-function...

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Identifiers

PMID: 23536755
DOI: 10.1371/journal.pone.0051456
PMCID: PMC3594205

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