Article
A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Jan 2011
Till Sally M, Li Hsiu-Ling, Miniaci Maria Concetta, Kandel Eric R, Choi Yun-Beom
Abstract excerpt
Loss of the Fragile X mental retardation protein (FMRP) is associated with presumed postsynaptic deficits in mouse models of Fragile X syndrome. However, the possible presynaptic roles of FMRP in learning-related plasticity have received little attention. As a result, the mechanisms whereby FMRP influences synaptic function remain poorly understood. To investigate the cellular locus of the effects of FMRP on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
