Article
Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1.
Biochemical and biophysical research communications - 8 Oct 2022
Apridita Sebastian Wulan, Shiraishi Hiroshi, Shimizu Nobuyuki, Umeda Ryohei, Lai Shaohong, Ikeuchi Mayo, Morisaki Ikuko, Yano Shinji, Yoshimura Akihiko, Hanada Reiko, Hanada Toshikatsu
Abstract excerpt
Autosomal recessive primary microcephaly (MCPH) is a rare congenital disorder characterized by a below average brain volume at birth and is associated with neurodevelopmental disorders such as growth retardation and intellectual disability. Mutations in ANKLE2 have been identified as one of the causes of MCPH (MCPH16). ANKLE2 is a target molecule of the Zika virus NS4a protein that interferes with ANKLE2...
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