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Article

The "anemic" enterocyte in hereditary hemochromatosis: molecular insights into the control of intestinal iron absorption.

Nutrition reviews - 1 May 2002

Wood Richard J

Abstract excerpt

Studies of the molecular function of HFE, the protein defective in hereditary hemochromatosis, have provided important insights into the control of intestinal iron absorption. A recent study suggests that HFE controls the recycling rate of the transferrin receptor and thereby ultimately controls the iron status of the enterocyte. In hereditary hemochromatosis, a defect in HFE causes relative iron starvation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

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Source

Identifiers

PMID: 12030278
DOI: 10.1301/00296640260093814

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The "anemic" enterocyte in hereditary hemochromatosis: molecular insights into the control of intestinal iron absorption.PMID 12030278Read ↗

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Molecular aspects of iron absorption and HFE expression.Semantic proximity Read ↗

Mechanistic and regulatory aspects of intestinal iron absorptionSemantic proximity Read ↗

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.Semantic proximity Read ↗

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.Semantic proximity Read ↗

Hfe acts in hepatocytes to prevent hemochromatosis.Semantic proximity Read ↗

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