Article
Hot-spot mutants of p53 core domain evince characteristic local structural changes.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999
Wong K B, DeDecker B S, Freund S M, Proctor M R, Bycroft M, Fersht A R
Abstract excerpt
Most of the oncogenic mutations in the tumor suppressor p53 map to its DNA-binding (core) domain. It is thus a potential target in cancer therapy for rescue by drugs. To begin to understand how mutation inactivates p53 and hence to provide a structural basis for drug design, we have compared structures of wild-type and mutant p53 core domains in solution by NMR spectroscopy. Structural changes introduced by five...
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