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Article

Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.

Nucleic acids research - 1 Sept 2011

De Ioannes Pablo, Escalante Carlos R, Aggarwal Aneel K

Abstract excerpt

Interferon regulatory factors IRF-3 and IRF-7 are transcription factors essential in the activation of interferon-β (IFN-β) gene in response to viral infections. Although, both proteins recognize the same consensus IRF binding site AANNGAAA, they have distinct DNA binding preferences for sites in vivo. The X-ray structures of IRF-3 and IRF-7 DNA binding domains (DBDs) bound to IFN-β promoter elements revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21596780
DOI: 10.1093/nar/gkr325
PMCID: PMC3167601

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