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Article

Exploring the intramolecular phosphorylation sites in human Chk2.

Mutation research - 10 Nov 2008

Olsen Birgitte B, Larsen Martin R, Boldyreff Brigitte, Niefind Karsten, Issinger Olaf-Georg

Abstract excerpt

A comparative biochemical analysis was performed using recombinant human protein kinase Chk2 (checkpoint kinase 2) expressed in bacteria and insect cells. Dephosphorylated, inactive, recombinant human Chk2 could be reactivated in a concentration-dependent manner. Despite distinct time-dependent autophosphorylation kinetics by monitoring the phosphorylation of amino acid residues T68, S19, S33/35, T432, in Chk2...

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PMID: 18812180
DOI: 10.1016/j.mrfmmm.2008.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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