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Article

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Molecular cell - 24 Sept 2009

Cai Zhenjian, Chehab Nabil H, Pavletich Nikola P

Abstract excerpt

The CHK2 protein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contributes to hereditary and sporadic cancer. CHK2 activation is triggered by the phosphorylation of Thr68 by the DNA damage-activated ATM kinase. This leads to transient CHK2 dimerization, in p...

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Source

Identifiers

PMID: 19782031
DOI: 10.1016/j.molcel.2009.09.007

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19782031-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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