Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.

Journal of virology - 1 Jun 2002

Van Rompay Koen K A, Matthews Tim B, Higgins Joanne, Canfield Don R, Tarara Ross P, Wainberg Mark A, Schinazi Raymond F, Pedersen Niels C, North Thomas W

Abstract excerpt

Drug-resistant mutants with a methionine-to-valine substitution at position 184 of reverse transcriptase (M184V) emerged within 5 weeks of initiation of therapy in four newborn macaques infected with simian immunodeficiency virus (SIVmac251) and treated with lamivudine (3TC) or emtricitabine [(-)-FTC] (two animals per drug). Thus, this animal model mimics the rapid emergence of M184V mutants of HIV-1 during 3TC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxycytidine
Share to Emtricitabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lamivudine

Share to Macaca mulatta

Share to Reverse Transcriptase Inhibitors

Share to RNA-Directed DNA Polymerase

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 12021341
DOI: 10.1128/jvi.76.12.6083-6092.2002
PMCID: PMC136201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.PMID 12021341Read ↗

The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus.Semantic proximity Read ↗

Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.Semantic proximity Read ↗

Evolution of Lamivudine Resistance in Human Immunodeficiency Virus Type 1-Infected Individuals: the Relative Roles of Drift and SelectionSemantic proximity Read ↗

In Vivo Fitness Cost of the M184V Mutation in Multidrug-Resistant Human Immunodeficiency Virus Type 1 in the Absence of LamivudineSemantic proximity Read ↗

9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA.Semantic proximity Read ↗

The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses.Semantic proximity Read ↗

The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response.Semantic proximity Read ↗

Effects of reverse-transcriptase mutations M184V and E89G on simian immunodeficiency virus in Rhesus monkeys.Semantic proximity Read ↗

HIV fitness and resistance as covariates associated with the appearance of mutations under antiretroviral treatment.Semantic proximity Read ↗

The impact of the M184V substitution on drug resistance and viral fitness.Semantic proximity Read ↗

Prophylactic and Therapeutic Benefits of Short-Term 9-[2-( R )-(Phosphonomethoxy)Propyl]Adenine (PMPA) Administration to Newborn Macaques following Oral Inoculation with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPASemantic proximity Read ↗

Might the M184V substitution in HIV-1 RT confer clinical benefit?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.