Article
9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA.
Antimicrobial agents and chemotherapy - 1 Apr 1999
Van Rompay K K, Cherrington J M, Marthas M L, Lamy P D, Dailey P J, Canfield D R, Tarara R P, Bischofberger N, Pedersen N C
Abstract excerpt
Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a useful animal model of human immunodeficiency virus infection for the study of the emergence and clinical implications of drug-resistant viral mutants. We previously demonstrated that SIV-infected infant macaques receiving prolonged treatment with 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) developed viral mutants with fivefold reduced...
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