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Article

Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.

Journal of virology - 1 Jan 2003

Murry Jeffrey P, Higgins Joanne, Matthews Timothy B, Huang Victoria Y, Van Rompay Koen K A, Pedersen Niels C, North Thomas W

Abstract excerpt

The methionine-to-valine mutation in codon 184 (M184V) in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) confers resistance to (-)-2'-deoxy-3'-thiacytidine (3TC; lamivudine) and increased sensitivity to 9-[2-(phosphonomethoxy)propyl]adenine (PMPA; tenofovir). We have used the SIV model to evaluate the effect of the M184V mutation on the emergence...

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Identifiers

PMID: 12502828
DOI: 10.1128/jvi.77.2.1120-1130.2003
PMCID: PMC140811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.PMID 12502828Read ↗

The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus.Semantic proximity Read ↗

Mutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.Semantic proximity Read ↗

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Neutralizing antibodies directed against the V3 loop select for different escape variants in a virus with mutated reverse transcriptase (M184V) than in wild-type human immunodeficiency virus type 1.Semantic proximity Read ↗

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Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture.Semantic proximity Read ↗

The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response.Semantic proximity Read ↗

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