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Article

BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage

1 Jan 2002

Abstract excerpt

PURPOSE: Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small number of samples as well as the present pilot study also suggested that BRCA1 heterozygosity may...

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PMID: 12020440
DOI: 10.1080/09553000110097974

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Source receipt: pubmed, retrieved 7 Sept 2026.

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