Article
Molecular aspects of steroidogenic factor 1 (SF-1).
Molecular and cellular endocrinology - 5 Feb 2010
Hoivik Erling A, Lewis Aurélia E, Aumo Linda, Bakke Marit
Abstract excerpt
Steroidogenic factor 1 (SF-1, also called Ad4BP and NR5A1) is a nuclear receptor with critical roles in steroidogenic tissues, as well as in the brain and pituitary. In particular, SF-1 has emerged as an essential regulator of adrenal and gonadal functions and development. In the last few years, our knowledge on SF-1 has increased considerably at all levels, from the gene to the protein, and on its specific roles...
Topics
- Animals
- Gene Dosage
- Gene Expression Regulation, Developmental
- Humans
- Mice
- Mice, Knockout
- Mutation
- Promoter Regions, Genetic
- Protein Processing, Post-Translational
- Steroidogenic Factor 1
- Transcription, Genetic