Article
Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.
Neuron - 1 Jul 1994
Montag D, Giese K P, Bartsch U, Martini R, Lang Y, Blüthmann H, Karthigasan J, Kirschner D A, Wintergerst E S, Nave K A
Abstract excerpt
Using homologous recombination in embryonic stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation. MAG-deficient mice appeared normal in motor coordination and spatial learning tasks. Normal myelin structure and nerve conduction in the PNS, with N-CAM overexpression at sites normally expressing...
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