Article
Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.
Neuron - 1 Jul 1994
Montag D, Giese K P, Bartsch U, Martini R, Lang Y, Blüthmann H, Karthigasan J, Kirschner D A, Wintergerst E S, Nave K A
Abstract excerpt
Using homologous recombination in embryonic stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation. MAG-deficient mice appeared normal in motor coordination and spatial learning t...
Topics
- Animals
- Base Sequence
- Behavior, Animal
- Brain
- Cell Adhesion Molecules, Neuronal
- DNA
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Myelin Proteins
- Myelin Sheath
- Myelin-Associated Glycoprotein
- Oligodendroglia