Article
No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.
The Journal of biological chemistry - 19 Jul 2002
Couplan Elodie, del Mar Gonzalez-Barroso Maria, Alves-Guerra Marie Clotilde, Ricquier Daniel, Goubern Marc, Bouillaud Frédéric
Abstract excerpt
The phenotypes observed in mice whose uncoupling protein (Ucp2) gene had been invalidated by homologous recombination (Ucp2(-/-) mice) are consistent with an increase in mitochondrial membrane potential in macrophages and pancreatic beta cells. This could support an uncoupling (proton transport) activity of UCP2 in the inner mitochondrial membrane in vivo. We used mitochondria from lung or spleen, the two organs...
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