Article
Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia.
Blood - 1 Jun 2002
Yuille Martin, Condie Alison, Hudson Chantelle, Kote-Jarai Zsofia, Stone Elaine, Eeles Rosalind, Matutes Estella, Catovsky Daniel, Houlston Richard
Abstract excerpt
Interindividual differences in susceptibility to hematologic malignancies may be mediated in part through polymorphic variability in the bioactivation and detoxification of carcinogens. The glutathione S-transferases (GSTs) have been implicated as susceptibility genes in this context for a number of cancers. The aim of this study was to examine whether polymorphic variation in GSTs confers susceptibility to...
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