Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia.

Carcinogenesis - 1 Jan 2000

Rollinson S, Roddam P, Kane E, Roman E, Cartwright R, Jack A, Morgan G J

Abstract excerpt

Polymorphisms within the phase II metabolizer enzymes GST T1, GST M1 and GST P1 affect the body's ability to detoxify a range of potential leukaemogens encountered in the environment. Using PCR, GST T1, GST M1 and GST P1 genotypes were determined in 557 adults with acute leukaemia and 952 age, sex and geographically matched controls. The strongest association with acute leukaemia was observed for the GST T1 null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to Glutathione Transferase
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Transcription, Genetic

Source

Identifiers

PMID: 10607732
DOI: 10.1093/carcin/21.1.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia.PMID 10607732Read ↗

Deletion of GSTM1 and T1 genes as a risk factor for development of acute leukemia.Semantic proximity Read ↗

Gluthatione-S-transferase T1-null genotype predisposes adults to acute promyelocytic leukemia; a case-control study.Semantic proximity Read ↗

Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia.Semantic proximity Read ↗

Risk effects of GST gene polymorphisms in patients with acute myeloid leukemia: a prospective study.Semantic proximity Read ↗

Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis.Semantic proximity Read ↗

Glutathione S-transferase gene polymorphisms and susceptibility to chronic myeloid leukemia.Semantic proximity Read ↗

Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children's Cancer Group study.Semantic proximity Read ↗

Glutathione S-transferase gene polymorphisms and susceptibility to acute myeloid leukemia: meta-analyses.Semantic proximity Read ↗

Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects.Semantic proximity Read ↗

Glutathione S-transferase M1 and T1 null genotype frequency in chronic myeloid leukaemia.Semantic proximity Read ↗

Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia.Semantic proximity Read ↗

Glutathione sulfur transferase M1 and T1 genotypes in chronic lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.