Article
The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease.
Experimental neurology - 1 May 2002
Armstrong Richard J E, Hurelbrink Carrie B, Tyers Pam, Ratcliffe Emma L, Richards Andrew, Dunnett Stephen B, Rosser Anne E, Barker Roger A
Abstract excerpt
Neural precursors with the properties of neural stem cells can be isolated from the developing brain, can be expanded in culture, and have been suggested as a potential source of cells for neuronal replacement therapies in degenerative disorders such as Parkinson's disease (PD). Under such conditions an improved spectrum of functional benefit may be obtained through homotypic reconstruction of degenerated neural...
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