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Article

Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.

Stem cell reports - 10 Jul 2018

Wang Yu-Kai, Zhu Wan-Wan, Wu Meng-Hua, Wu Yi-Hui, Liu Zheng-Xin, Liang Ling-Min, Sheng Chao, Hao Jie, Wang Liu, Li Wei, Zhou Qi, Hu Bao-Yang

Abstract excerpt

Clinical application of stem cell derivatives requires clinical-grade cells and sufficient preclinical proof of safety and efficacy, preferably in primates. We previously successfully established a clinical-grade human parthenogenetic embryonic stem cell (hPESC) line, but the suitability of its subtype-specific progenies for therapy is not clear. Here, we compared the function of clinical-grade hPESC-derived...

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Cell- and Tissue-Based Therapy
Dopamine
Dopaminergic Neurons
Embryonic Stem Cells
Locomotion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neural Stem Cells

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Identifiers

PMID: 29910127
DOI: 10.1016/j.stemcr.2018.05.010
PMCID: PMC6067059

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